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Normal Tissue Gallery Topoisomerase 2-alpha
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Adrenal gland
Adrenal gland
Aorta, media
Aorta, media
Appendix, mucosa - TOPO2A positive cells in the appendix mucosa reflect proliferating cells.
Appendix, mucosa – TOPO2A positive cells in the appendix mucosa reflect proliferating cells.
Appendix, muscular wall
Appendix, muscular wall
Bone marrow
Bone marrow
Breast
Breast
Bronchus, mucosa
Bronchus, mucosa
Cerebellum (molecular layer, Purkinje cell layer, granule cell layer)
Cerebellum (molecular layer, Purkinje cell layer, granule cell layer)
Cerebellum (molecular layer, Purkinje cell layer, granule cell layer, white matter)
Cerebellum (molecular layer, Purkinje cell layer, granule cell layer, white matter)
Cerebrum, grey matter
Cerebrum, grey matter
Cerebrum, white matter
Cerebrum, white matter
Colon descendens, muscular wall
Colon descendens, muscular wall
Colon, mucosa
Colon, mucosa
Duodenum, Brunner gland
Duodenum, Brunner gland
Duodenum, mucosa
Duodenum, mucosa
Epididymis
Epididymis
Esophagus, squamous epithelium
Esophagus, squamous epithelium
Fallopian tube, mucosa
Fallopian tube, mucosa
Fat
Fat
Gallbladder, epithelium
Gallbladder, epithelium
Heart muscle
Heart muscle
Ileum, mucosa - TOPO2A positive cells in the ileum mucosa reflect proliferating cells.
Ileum, mucosa – TOPO2A positive cells in the ileum mucosa reflect proliferating cells.
Kidney, cortex
Kidney, cortex
Kidney, medulla
Kidney, medulla
Liver
Liver
Lung
Lung
Lymph node
Lymph node
Ovary, stroma
Ovary, stroma
Pancreas
Pancreas
Parathyroid gland
Parathyroid gland
Parotid gland
Parotid gland
Pituitary gland, anterior lobe
Pituitary gland, anterior lobe
Pituitary gland, posterior lobe
Pituitary gland, posterior lobe
Placenta (amnion and chorion)
Placenta (amnion and chorion)
Placenta, early
Placenta, early
Pregnant uterus (decidua)
Pregnant uterus (decidua)
Placenta, mature
Placenta, mature
Prostate
Prostate
Rectum, mucosa
Rectum, mucosa
Seminal vesicle
Seminal vesicle
Sinus paranasales, epithelium
Sinus paranasales, epithelium
Skeletal muscle
Skeletal muscle
Skin - TOPO2A immunostaining is seen seen in proliferating cells.
Skin – TOPO2A immunostaining is seen seen in proliferating cells.
Spleen
Spleen
Stomach, antrum - TOPO2A positive cells in the stomach antrum reflect proliferating cells.
Stomach, antrum – TOPO2A positive cells in the stomach antrum reflect proliferating cells.
Stomach, corpus - TOPO2A positive cells in the stomach corpus reflect proliferating cells.
Stomach, corpus – TOPO2A positive cells in the stomach corpus reflect proliferating cells.
Testis - Spermatocyte of the testis – subject to meiosis - is the only normal cell type with a consistent strong TOPO2A expression in virtually all cells.
Testis – Spermatocyte of the testis – subject to meiosis – is the only normal cell type with a consistent strong TOPO2A expression in virtually all cells.
Thymus - The highest rate of TOPO2A positive lymphocytes is seen in the thymus (cortex).
Thymus – The highest rate of TOPO2A positive lymphocytes is seen in the thymus (cortex).
Thyroid gland
Thyroid gland
Tonsil - In the tonsil, TOPO2A positive lymphocytes are predominantly seen in germinal centres.
Tonsil – In the tonsil, TOPO2A positive lymphocytes are predominantly seen in germinal centres.
Tonsil, surface epithelium - In the tonsil, TOPO2A immunostaining can regularly be seen in epithelial cells and lymphocytes with a distribution pattern consistent with proliferating cells.
Tonsil, surface epithelium – In the tonsil, TOPO2A immunostaining can regularly be seen in epithelial cells and lymphocytes with a distribution pattern consistent with proliferating cells.
Urinary bladder, muscular wall
Urinary bladder, muscular wall
Urinary bladder, urothelium
Urinary bladder, urothelium
Uterus, ectocervix - Few proliferating cells show TOPO2A immunostaining.
Uterus, ectocervix – Few proliferating cells show TOPO2A immunostaining.
Uterus, endocervix
Uterus, endocervix
Uterus, endometrium (proliferation)
Uterus, endometrium (proliferation)
Uterus, endometrium (secretion)
Uterus, endometrium (secretion)
Uterus, myometrium
Uterus, myometrium