Cancer Tissue Gallery Topoisomerase 2-alpha

Breast – Invasive lobular carcinoma with TOPO2A positivity in 5-10% of tumor cells.

Colon – Colorectal adenocarcinoma with TOPO2A immunostaining in >50% of tumor cells.

Esophagus – Adenocarcinoma with TOPO2A positivity of >60% of tumor cells.

Esophagus – Squamous cell carcinoma with TOPO2A positivity in about 20% of tumor cells.

Kidney – Clear cell renal cell carcinoma with TOPO2A positivity of 1-2% of tumor cells.

Kidney – Oncocytoma showing TOPO2A immunostaining in <1% of tumor cells.

Kidney – Papillary renal cell carcinoma with TOPO2A immunostaining in 1-2% of tumor cells.

Oral cavity – Squamous cell carcinoma with TOPO2A positivity in 20-30% of tumor cells.

Ovary – Clear cell carcinoma with TOPO2A positivity in about 10% of tumor cells.

Ovary – Serous high-grade carcinoma with TOPO2A positivity in about 10-15% of tumor cells.

Pharynx – Squamous cell carcinoma with TOPO2A positivity in <10% of tumor cells.

Prostate – Adenocarcinoma (Gleason 3+3=6) with TOPO2A immunostaining in 1-3% of tumor cells.

Thyroid – Follicular carcinoma with TOPO2A immunostaining in about 1% of tumor cells.

Urinary bladder – Muscle-invasive urothelial carcinoma showing TOPO2A immunostaining in 60-75% of tumor cells.