Adrenal gland - Adrenocortical adenoma with a weak to moderate , mostly membranous Synaptophysin immunostaining in about 50% of tumor cells.
Adrenal gland - Adrenocortical adenoma with a weak Synaptophysin immunostaining in few tumor cells.
Adrenal gland - Moderate to strong Synaptophysin positivity in an adrenocortical adenoma.
Adrenal gland - Pheochromocytoma with strong, diffuse Synaptophysin positivity in all tumor cells.
Breast - Invasive breast cancer of no special type (NST) exhibiting a weak to moderate Synaptophysin immunostaining of all tumor cells.
Breast - Synaptophysin negative invasive breast cancer of no special type (NST).
Lung - Small cell carcinoma showing a moderate Synaptophysin immunostaining of all tumor cells.
Lung - Synaptophysin negative adenocarcinoma.
Pancreas - Neuroendocrine tumor exhibiting strong cytoplasmic Synaptophysin immunostaining of tumor cells.
Prostate - Synaptophysin negative adenocarcinoma (Gleason 3+3=6).
Prostate - Synaptophysin positive adenocarcinoma (Gleason 5+5=10).
Retroperitoneum - Diffuse, moderate to strong Synaptophysin immunostaining of all cells of a leiomyosarcoma.
Skin - Merkel cell carcinoma displaying an intense cytoplasmic Synaptophysin immunostaining of all tumor cells.
Skin - Synaptophysin negative basal cell carcinoma.
Stomach - Synaptophysin negative adenocarcinoma (intestinal type).
Thyroid - Medullary carcinoma with strong cytoplasmic Synaptophysin immunostaining of all tumor cells.
Urinary bladder - Small cell carcinoma with diffuse, intense cytoplasmic Synaptophysin positivity.