Normal Tissue Gallery Villin

Adrenal gland

Aorta, media

Appendix, mucosa – Villin immunostaining is predominantly membranous but also cytoplasmic and often shows a strong focus on the apical/luminal membranes.

Appendix, muscular wall

Bone marrow

Breast

Bronchus, mucosa

Cerebellum (molecular layer, Purkinje cell layer, granule cell layer, white matter)

Cerebellum (white matter)

Cerebrum, grey matter

Cerebrum, white matter

Colon descendens, mucosa – Colon epithelial cells show a strong, predominantly membranous but also cytoplasmic villin immunostaining.

Colon descendens, muscular wall

Duodenum, Brunner gland

Duodenum, mucosa – Villin immunostaining is predominantly membranous but also cytoplasmic and often shows a strong focus on the apical/luminal membranes in the duodenum mucosa.

Ectocervix

Endocervix

Endometrium, proliferation

Endometrium, secretion

Endometrium, secretion

Epididymis – A moderate villin staining is seen in ciliated columnar cells in the epididymis.

Epididymis

Esophagus, squamous epithelium

Fat

Gallbladder, epithelium – Villin immunostaining is particularly strong in the gallbladder epithelium.

Heart

Ileum, mucosa – Villin immunostaining is predominantly membranous but also cytoplasmic and often shows a strong focus on the apical/luminal membranes in epithelial cells of the small intestine.

Kidney cortex – A strong villin positivity is seen in proximal tubuli of the kidney but not in distal tubuli or glomeruli.

Kidney, medulla – Absence of villin immunostaining in collecting ducts of the kidney.

Liver – In the liver a weak to moderate villin staining is seen at the apical pole of hepatocytes. The expression level exhibits a zonal variability.

Lung

Lymph node

Ovary, stroma

Pancreas – In the pancreas, a strong villin positivity is seen in interlobular ducts. In addition, a weak to moderate villin staining is seen at the apical pole of acinar cells.

Parathyroid

Parotid gland

Pituitary gland, anterior lobe

Pituitary gland, posterior lobe

Pregnant uterus (decidua)

Placenta, early

Placenta, mature

Placenta (amnion and chorion)

Prostate

Rectum, mucosa

Seminal vesicle

Sinus paranasales

Skin

Spleen

Stomach, antrum – The surface epithelium of the stomach shows a weak, sometimes moderate villin immunostaining with decreasing intensity towards the base of the glands (which are villin negative).

Stomach, corpus – Villin negative gastric corpus glands.

Testis

Thymus

Thyroid gland

Tonsil, surface epithelium

Tonsil

Urinary bladder, muscular wall

Urinary bladder, urothelium

Uterus, myometrium