Normal Tissue Gallery S100

Adrenal gland

Adrenal gland – S100B positivity is seen in sustentacular cells and also in a fraction of medullary cells.

Aorta, media

Appendix, mucosa – Appendix with a multitude of intramucosal S100B positive nerve fibres.

Appendix, muscular wall – S100B positive nerve fibres are abundant in the muscular wall of the appendix.

Bone marrow – Fat cells are S100B positive.

Breast – Strong S100B immunostaining in myoepithelial cells while staining is much weaker in luminal breast epithelial cells.

Bronchus, mucosa – Strong S100B immunostaining in some serous cells of bronchial glands.

Cerebellum (molecular layer, Purkinje cell layer, granule cell layer, white matter) – Strong ubiquitous S100B staining in the cerebellum.

Cerebellum (molecular layer, Purkinje cell layer, granule cell layer, white matter) – Strong ubiquitous S100B staining in the cerebellum.

Cerebrum, grey matter – Strong ubiquitous S100B staining (except neurons).

Cerebrum, white matter – Strong ubiquitous S100B staining.

Colon descendens, mucosa

Colon descendens, muscular wall – Nerve fibres and ganglion cells are S100B positive.

Duodenum, Brunner gland

Duodenum, mucosa – A large number of S100B positive nerve fibres is seen in this sample from the duodenum.

Ectocervix

Endocervix

Endometrium, proliferation

Endometrium, secretion

Epididymis

Esophagus, squamous epithelium

Fallopian tube, mucosa

Fat – Fat cells are S100B positive.

Gallbladder, epithelium

Heart

Ileum, mucosa

Ileum, mucosa – Strong S100B staining of nerve fibres.

Kidney, cortex

Kidney, medulla

Liver

Lung

Lymph node – Strong S100B immunostaining is seen in a subset of T-lymphocytes.

Ovary, follicular cyst – Moderate S100B staining in granulosa cells of a follicular cyst of the ovary.

Ovary, follicular cyst – Follicular cyst of the ovary showing a moderate S100B staining of granulosa cells.

Ovary, stroma – Few S100B positive nerve fibres are visible in the ovarian stroma.

Pancreas

Parathyroid – S100B positivity is seen in fat cells.

Parotid gland – Strong S100B staining of nerves and fat cells.

Parotid gland – S100B positivity is seen in myoepithelial cells, nerve fibres, and fat cells.

Pituitary gland, anterior lobe

Pituitary gland, anterior lobe – A weak S100B staining can be seen in a fraction of cells in the adenohypophysis.

Pituitary gland, posterior lobe

Pregnant uterus (decidua)

Placenta, early

Placenta, mature

Placenta (amnion and chorion)

Prostate

Rectum, mucosa

Seminal vesicle

Sinus paranasales

Skin – Langerhans cells show strong S100B positivity.

Spleen – Strong S100B immunostaining is seen in a subset of T-lymphocytes.

Stomach, antrum

Stomach, corpus

Testis

Thymus – S100P staining of a fraction of thymus epithelial cells and possibly also of lymphocytes.

Tongue, muscle

Tonsil, surface epithelium

Tonsil

Thyroid gland

Urinary bladder, muscular wall

Urinary bladder, urothelium

Uterus, myometrium