Adrenal gland: Individual cells or small groups of normally appearing adrenocortical cells can occasionally show a weak to moderate p16 immunostaining.
Aorta, media
Appendix, mucosa: Few individual cells or small groups of cells with weak to moderate p16 immunostaining can occasionally occur in gastrointestinal epithelium.
Appendix, muscular wall
Breast: Few individual luminal epithelial cells with weak to moderate p16 immunostaining can occasionally occur.
Bronchus, mucosa
Cerebellum (molecular layer)
Cerebellum (molecular layer, Purkinje cell layer, granule cell layer)
Cerebrum, grey matter
Cerebrum, white matter
Colon descendens, mucosa
Colon descendens, muscular wall
Duodenum, Brunner gland
Duodenum, mucosa: Few individual cells with weak to moderate p16 immunostaining can occasionally occur in gastrointestinal epithelium.
Ectocervix
Endocervix
Endometrium, proliferation
Endometrium, proliferation: Some glands with weak to moderate p16 immunostaining in the majority of cells can be seen in the histologically normal endometrium (not in all cases).
Endometrium, secretion: Some glands with weak to moderate p16 immunostaining in the majority of cells is often seen in the histologically normal endometrium.
Epididymis
Esophagus, squamous epithelium
Fallopian tube, mucosa
Fat
Gallbladder, epithelium
Heart
Ileum, mucosa
Kidney, cortex
Kidney, medulla
Liver
Lung
Lymph node
Ovary, stroma
Pancreas- A fraction of cells of islets of Langerhans show a moderate p16 staining
Parathyroid
Parotid gland
Pituitary gland, anterior lobe: A subset of cells of the adenohypophysis regularly show a moderate to strong p16 immunostaining.
Pregnant uterus (decidua)
Placenta, early
Placenta, mature
Placenta, mature: A weak to moderate p16 immunostaining can occur in stroma cells of the placenta (only in individual cases)
Placenta (amnion and chorion)
Prostate: Basal cells can show a weak to moderate p16 staining.
Rectum, mucosa
Seminal vesicle: Occasional coloration of the seminal vesicle epithelial cells is due to pigmentation (no true immunostaining).
Sinus paranasales: Few individual cells or groups of cells with weak to moderate p16 immunostaining can occasionally occur in respiratory epithelium.
Skin
Spleen
Stomach, antrum
Stomach, corpus
Striated muscle
Testis
Thymus: Some elements of corpuscles of Hassall's stain p16 positive.
Thyroid gland
Tonsil: individual cells or small groups of normally appearing squamous epithelial cells of the crypts can occasionally show weak to moderate p16 immunostaining.
Tonsil, surface epithelium: Individual cells or small groups of normally appearing cells with weak to moderate p16 immunostaining can occasionally occur in the surface epithelium.
Urinary bladder, muscular wall
Urinary bladder, urothelium: Occasional cells or small groups of normally appearing cells with weak to moderate p16 immunostaining can occur in urothelium (here: mostly umbrella cells). Very rarely, this also applies to few stroma cells such as in this case.
Uterus, myometrium