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Normal Tissue Gallery MTAP
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Adrenal gland – Moderate to strong, nuclear and cytoplasmic MTAP positivity of epithelial cells
Adrenal gland – Moderate to strong, nuclear and cytoplasmic MTAP positivity of epithelial cells
Aorta, endothelium
Aorta, endothelium
Appendix, muscular wall
Appendix, muscular wall
Bone marrow
Bone marrow
Breast – Intense, nuclear and cytoplasmic MTAP positivity of epithelial cells
Breast – Intense, nuclear and cytoplasmic MTAP positivity of epithelial cells
Bronchus, mucosa
Bronchus, mucosa
Cerebellum (white matter) – Faint to moderate staining in some glia cells
Cerebellum (white matter) – Faint to moderate staining in some glia cells
Cerebellum, cortex (molecular layer, Purkinje cell layer, granule cell layer) – Faint to moderate staining in small blood vessels and in some glia cells
Cerebellum, cortex (molecular layer, Purkinje cell layer, granule cell layer) – Faint to moderate staining in small blood vessels and in some glia cells
Cerebrum, grey matter – Weak to moderate staining in small blood vessels and in some glia cells
Cerebrum, grey matter – Weak to moderate staining in small blood vessels and in some glia cells
Cerebrum, white matter
Cerebrum, white matter
Colon descendens, mucosa
Colon descendens, mucosa
Colon descendens, muscular wall
Colon descendens, muscular wall
Duodenum, Brunner gland
Duodenum, Brunner gland
Duodenum, mucosa – Weak to moderate, predominantly cytoplasmic MTAP positivity of epithelial cells. Note- Mucus in goblet cells is MTAP negative
Duodenum, mucosa – Weak to moderate, predominantly cytoplasmic MTAP positivity of epithelial cells. Note- Mucus in goblet cells is MTAP negative
Epididymis (cauda) – Strong, predominantly cytoplasmic MTAP positivity of epithelial cells
Epididymis (cauda) – Strong, predominantly cytoplasmic MTAP positivity of epithelial cells
Fallopian tube, mucosa – Moderate to strong, nuclear and cytoplasmic MTAP positivity of a subset of epithelial cells
Fallopian tube, mucosa – Moderate to strong, nuclear and cytoplasmic MTAP positivity of a subset of epithelial cells
Fat
Fat
Gallbladder, epithelium – Weak to moderate, predominantly nuclear MTAP positivity of epithelial cells
Gallbladder, epithelium – Weak to moderate, predominantly nuclear MTAP positivity of epithelial cells
Heart muscle – Faint cytoplasmic and sometimes also nuclear MTAP positivity of heart muscle cells
Heart muscle – Faint cytoplasmic and sometimes also nuclear MTAP positivity of heart muscle cells
Ileum, mucosa
Ileum, mucosa
Kidney, cortex – Weak nuclear and cytoplasmic MTAP positivity of tubular cells
Kidney, cortex – Weak nuclear and cytoplasmic MTAP positivity of tubular cells
Kidney, medulla – Moderate to strong, predominantly cytoplasmic MTAP positivity of tubular and collecting duct cells
Kidney, medulla – Moderate to strong, predominantly cytoplasmic MTAP positivity of tubular and collecting duct cells
Liver – MTAP staining can be rather weak in hepatocytes
Liver – MTAP staining can be rather weak in hepatocytes
Liver – Weak to moderate, cytoplasmic MTAP positivity hepatocytes in this sample
Liver – Weak to moderate, cytoplasmic MTAP positivity hepatocytes in this sample
Lung
Lung
Lymph node – Moderate to strong, predominantly cytoplasmic MTAP positivity of virtually all lymphocytes. Staining is most intense in the interfollicular area and least in germinal centres
Lymph node – Moderate to strong, predominantly cytoplasmic MTAP positivity of virtually all lymphocytes. Staining is most intense in the interfollicular area and least in germinal centres
Ovary, corpus luteum
Ovary, corpus luteum
Ovary, stroma – Moderate to strong, nuclear and cytoplasmic MTAP positivity of stromal cells
Ovary, stroma – Moderate to strong, nuclear and cytoplasmic MTAP positivity of stromal cells
Pancreas
Pancreas
Parathyroid gland – Moderate intensity, predominantly cytoplasmic MTAP positivity of epithelial cells
Parathyroid gland – Moderate intensity, predominantly cytoplasmic MTAP positivity of epithelial cells
Parotid gland
Parotid gland
Pituitary, anterior lobe – Moderate to strong, predominantly cytoplasmic MTAP positivity of epithelial cells
Pituitary, anterior lobe – Moderate to strong, predominantly cytoplasmic MTAP positivity of epithelial cells
Pituitary, posterior lobe – Weak, predominantly cytoplasmic MTAP staining of pituicytes
Pituitary, posterior lobe – Weak, predominantly cytoplasmic MTAP staining of pituicytes
Placenta (amnion and chorion) – Moderate to strong, nuclear and cytoplasmic MTAP positivity of chorion and amnion cells
Placenta (amnion and chorion) – Moderate to strong, nuclear and cytoplasmic MTAP positivity of chorion and amnion cells
Placenta, early – Strong, nuclear and cytoplasmic MTAP positivity of cytotrophoblast cells. MTAP staining is markedly less intense in the syncytiotrophoblast and in the stroma
Placenta, early – Strong, nuclear and cytoplasmic MTAP positivity of cytotrophoblast cells. MTAP staining is markedly less intense in the syncytiotrophoblast and in the stroma
Placenta, mature – Moderate to strong, nuclear and cytoplasmic MTAP positivity of cytotrophoblast cells. Staining is less intense in the syncytiotrophoblast and in the stroma
Placenta, mature – Moderate to strong, nuclear and cytoplasmic MTAP positivity of cytotrophoblast cells. Staining is less intense in the syncytiotrophoblast and in the stroma
Prostate – Moderate intensity, predominantly cytoplasmic MTAP positivity of epithelial cells
Prostate – Moderate intensity, predominantly cytoplasmic MTAP positivity of epithelial cells
Rectum, mucosa – Weak to moderate, predominantly cytoplasmic MTAP positivity of epithelial cells, especially seen at the base of crypts. Note- Mucus in goblet cells is MTAP negative
Rectum, mucosa – Weak to moderate, predominantly cytoplasmic MTAP positivity of epithelial cells, especially seen at the base of crypts. Note- Mucus in goblet cells is MTAP negative
Seminal vesicle – Moderate intensity, predominantly cytoplasmic MTAP positivity of epithelial cells
Seminal vesicle – Moderate intensity, predominantly cytoplasmic MTAP positivity of epithelial cells
Sinus paranasales
Sinus paranasales
Skeletal muscle
Skeletal muscle
Skin – Predominantly nuclear MTAP staining is strongest in the basal and suprabasal cell layers of the epidermis
Skin – Predominantly nuclear MTAP staining is strongest in the basal and suprabasal cell layers of the epidermis
Skin, hairfollicel and sebaceous glands
Skin, hairfollicel and sebaceous glands
Spleen – Moderate to strong, predominantly cytoplasmic MTAP positivity of inflammatory cells, especially in the white pulp
Spleen – Moderate to strong, predominantly cytoplasmic MTAP positivity of inflammatory cells, especially in the white pulp
Stomach, antrum – Moderate intensity, predominantly cytoplasmic MTAP positivity of gastric epithelium
Stomach, antrum – Moderate intensity, predominantly cytoplasmic MTAP positivity of gastric epithelium
Stomach, corpus – Moderate intensity, predominantly cytoplasmic MTAP positivity of gastric epithelium
Stomach, corpus – Moderate intensity, predominantly cytoplasmic MTAP positivity of gastric epithelium
Testis – Moderate to strong, nuclear and cytoplasmic MTAP positivity of spermatogonia. MTAP staining of other intratubular cells is markedly weaker or even absent. Strong positivity of Leydig cells
Testis – Moderate to strong, nuclear and cytoplasmic MTAP positivity of spermatogonia. MTAP staining of other intratubular cells is markedly weaker or even absent. Strong positivity of Leydig cells
Thymus – Moderate, predominantly cytoplasmic MTAP positivity of the majority of lymphocytes
Thymus – Moderate, predominantly cytoplasmic MTAP positivity of the majority of lymphocytes
Thyroid gland – Moderate intensity nuclear and cytoplasmic MTAP positivity of epithelial cells
Thyroid gland – Moderate intensity nuclear and cytoplasmic MTAP positivity of epithelial cells
Tonsil – In the squamous epithelium, a variable, predominantly nuclear MTAP is strongest in the basal and suprabasal cell layers
Tonsil – In the squamous epithelium, a variable, predominantly nuclear MTAP is strongest in the basal and suprabasal cell layers
Tonsil, surface epithelium – Cytoplasmic and nuclear MTAP staining is strongest in the basal and suprabasal epithelial cell layers
Tonsil, surface epithelium – Cytoplasmic and nuclear MTAP staining is strongest in the basal and suprabasal epithelial cell layers
Tonsil
Tonsil
Urinary bladder, muscular wall
Urinary bladder, muscular wall
Urinary bladder, urothelium – Strong, nuclear and cytoplasmic MTAP positivity of all urothelial cells
Urinary bladder, urothelium – Strong, nuclear and cytoplasmic MTAP positivity of all urothelial cells
Uterus, ectocervix – Cytoplasmic and nuclear MTAP staining predominantly occurs in in the basal and suprabasal epithelial cell layers
Uterus, ectocervix – Cytoplasmic and nuclear MTAP staining predominantly occurs in in the basal and suprabasal epithelial cell layers
Uterus, endocervix
Uterus, endocervix
Uterus, endometrium (pregnancy)
Uterus, endometrium (pregnancy)
Uterus, endometrium (proliferation) – Weak to moderate, predominantly cytoplasmic MTAP positivity of epithelial cells while staining is only faint in the stroma
Uterus, endometrium (proliferation) – Weak to moderate, predominantly cytoplasmic MTAP positivity of epithelial cells while staining is only faint in the stroma
Uterus, endometrium (secretion) – Intense, predominantly cytoplasmic MTAP positivity of epithelial cells while MTAP staining is markedly weaker in the stroma
Uterus, endometrium (secretion) – Intense, predominantly cytoplasmic MTAP positivity of epithelial cells while MTAP staining is markedly weaker in the stroma
Uterus, myometrium – Weak, predominantly cytoplasmic MTAP positivity of muscle cells
Uterus, myometrium – Weak, predominantly cytoplasmic MTAP positivity of muscle cells