Normal Tissue Gallery MCM7

Adrenal gland – A variable MCM7 staining occurs in a small fraction of adrenocortical cells

Aorta, media

Appendix, mucosa – MCM7 immunostaining predominates in in epithelial cells of the crypts. Some lymphocytes are also positive

Appendix, muscular wall

Breast – A weak to moderate MCM7 staining occurs in many luminal cells

Bronchus, mucosa – MCM7 staining occurs in a fraction of (mostly basal) respiratory epithelial cells

Cerebellum (molecular layer, Purkinje cell layer, granule cell layer)

Cerebellum (white matter)

Cerebrum, grey matter

Cerebrum, white matter

Colon descendens, muscular wall

Colon, descendes – MCM7 staining predominates in epithelial cells of the crypts

Duodenum, Brunner gland

Duodenum, mucosa – MCM7 immunostaining predominates in epithelial cells of the crypts

Epididymis – Only few cells show a weak to moderate MCM7 staining

Esophagus, muscular wall – Faint MCM7 immunostaining in some smooth muscle cells

Esophagus, squamous epithelium – Esophageal squamous epithelium shows a moderate to strong MCM7 staining of suprabasal and basal cells

Fallopian tube, mucosa – MCM7 staining in a significant fraction of epithelial cells

Fat

Gallbladder, epithelium – Few MCM7 positive cells occur in the gallbladder epithelium

Heart muscle – Faint MCM7 staining in some muscle cells

Ileum, mucosa – MCM7 staining predominates in epithelial cells of the crypts

Kidney, cortex – Only few cells are MCM7 positive

Kidney, medulla

Kidney, pelvis (muscular wall) – Faint MCM7 immunostaining in some smooth muscle cells

Liver – MCM7 staining of variable intensity in a small fraction of hepatocytes

Lung

Lymph node – Many lymphocytes are MCM7 positive. A particularly strong MCM7 staining occurs in most cells of germinal centres and in scattered individual cells of the interfollicular zone

Ovary, stroma

Pancreas – MCM7 staining occurs in a small fraction of pancreatic epithelial cells. The rate of positive cells is particularly low in islets of Langerhans

Parathyroid gland – MCM7 staining in a small fraction of parathyroideal cells

Parotid gland

Pituitary gland, anterior lobe

Pituitary gland, posterior lobe

Placenta (amnion and chorion)

Placenta, early – MCM7 staining in many cells of the cytotrophoblast and a fraction of stroma cells

Placenta, mature – Cells of the cytotrophoblast and also some stroma cells show strong MCM7 staining

Prostate – MCM7 staining is more common in basal than in acinar epithelial cells

Rectum, mucosa – MCM7 immunostaining predominates in in epithelial cells of the crypts. Some lymphocytes are also positive

Seminal vesicle

Sinus paranasales – MCM7 staining occurs in a fraction of (mostly basal) respiratory epithelial cells

Skeletal muscle – Significant MCM7 staining in a fraction of skeletal muscle cells

Skin – In the squamous epithelium of the skin, suprabasal and (weaker) basal cell layers show a distinct MCM7 immunostaining

Spleen – Most lymphocytes of the white pulp are MCM7 positive. A strong MCM7 positivity occurs in scattered cells of all compartments

Stomach, antrum – Strong MCM7 immunostaining in many mucous neck cells

Stomach, corpus – Strong MCM7 immunostaining in many mucous neck cells

Strong MCM7 immunostaining in the majority of bone marrow cells

Testis – Most spermatocytes show strong MCM7 positivity but mature sperms and probably also spermatogonia are MCM7 negative

Thymus – A strong MCM7 positivity occurs in most cells of the thymic cortex

Thyroid gland

Tonsil, surface epithelium – Moderate to strong MCM7 staining of suprabasal and basal squamous epithelial cells. A fraction of lymphocytes are also MCM7 positive

Urinary bladder, muscular wall

Urinary bladder, urothelium – Only few (suprabasal) urothelial cells show a MCM7 staining

Uterus, ectocervix – The squamous epithelium shows a moderate MCM7 immunostaining of (mostly) suprabasal cells

Uterus, endocervix – Only few epithelial cells show MCM7 staining

Uterus, endometrium (pregnancy) – MCM7 staining is rare in decidua cells

Uterus, endometrium (proliferation) – Almost all epithelial cells and a fraction of stromal cells are MCM7 positive

Uterus, endometrium (secretion) – The fraction of MCM7 positive epithelial cells is lower in the secretion phase

Uterus, myometrium – Faint MCM7 immunostaining in some muscle cells