Normal Tissue Gallery Desmoglein 3

Adrenal gland

Aorta, media

Appendix, mucosa

Appendix, muscular wall

Bone marrow

Breast

Bronchus, mucosa – A weak membranous Dsg3 immunostaining is seen in basal cells of respiratory epithelium.

Cerebellum (molecular, Purkinje cell, granule cell layers; white matter)

Cerebellum (molecular layer, Purkinje cell layer, granule cell layer, white matter)

Cerebrum, grey matter

Cerebrum, white matter

Colon descendens, mucosa

Colon descendens, muscular wall

Duodenum, Brunner gland

Duodenum, mucosa – A weak membranous, predominantly apical Dsg3 immunostaining is seen in the crypt base of epithelium of the small intestine.

Epididymis

Esophagus, squamous epithelium – Membranous Dsg3 immunostaining is predominantly seen in basal and suprabasal squamous epithelial cells.

Fallopian tube, mucosa

Fat

Gallbladder, epithelium

Heart muscle

Ileum, mucosa – A weak membranous, predominantly apical Dsg3 immunostaining is seen in the crypt base of epithelium of the small intestine.

Kidney, cortex

Kidney, medulla

Liver

Lung

Lymph node

Ovary, stroma

Pancreas

Parathyroid

Parotid gland

Pituitary gland, anterior lobe

Pituitary gland, posterior lobe

Placenta (amnion and chorion) – A weak membranous, predominantly apical Dsg3 immunostaining is seen in amnion cells.

Placenta, early

Placenta, mature

Prostate

Rectum, mucosa

Seminal vesicle

Sinus paranasales

Skeletal muscle

Skin – Moderate intensity Dsg3 immunostaining of basal and suprabasal epithelial cells.

Skin – Moderate to strong Dsg3 immunostaining of squamous epithelial epithelial cells of hair follicles.

Spleen

Stomach, antrum

Stomach, corpus

Testis

Thymus – Dsg3 immunostaining occurs in corpuscles of Hassall’s and (weaker) also in other thymic epithelial cells.

Thyroid gland

Tonsil – Squamous epithelial cells of the tonsil crypts show a Dsg3 immunostaining of variable intensity.

Tonsil, surface epithelium – Membranous Dsg3 immunostaining is strongest in basal and suprabasal epithelial cells.

Urinary bladder, muscular wall

Urinary bladder, urothelium – A membranous Dsg3 immunostaining is focally seen in basal and suprabasal urothelial cells in a sample showing inflammation (intraurothelial granulocytes).

Urinary bladder, urothelium – Dsg3 immunostaining is usually absent in the urothelium.

Uterus, ectocervix – Significant membranous Dsg3 immunostaining of all cell layers.

Uterus, endocervix

Uterus, endometrium (pregnancy)

Uterus, endometrium (proliferation)

Uterus, endometrium (secretion)

Uterus, myometrium