Normal Tissue Gallery Cytokeratin 5

Adrenal gland

Aorta, media

Appendix, mucosa

Appendix, muscular wall

Bone marrow

Breast – KRT5 staining can be very weak in myoepithelial cells of the breast.

Bronchus, mucosa – Cytokeratin 5 is expressed in basal cells of respiratory epithelium as well as in myoepithelial cells of bronchial glands.

Cerebellum (molecular layer, Purkinje cell layer, granule cell layer)

Cerebellum (granule cell layer, white matter)

Cerebrum, grey matter

Cerebrum, white matter

Colon descendens, mucosa

Duodenum, Brunner gland

Duodenum, mucosa

Ectocervix – KRT5 staining is usually seen in all layers of non-keratinizing squamous epithelium, but superficial layers stain sometimes slightly weaker.

Endocervix – Some basal cells can show KRT5 staining in endocervical glands.

Endocervix

Endometrium, proliferation

Endometrium, proliferation – Few endometrial epithelial cells (not all glands and only in a few samples) can show KRT5 immunostaining.

Endometrium, secretion

Epididymis – Basal cells of the epididymis show strong and columnar cells weak KRT5 immunostaining.

Esophagus, squamous epithelium

Fallopian tube, mucosa

Fat

Gallbladder, epithelium

Heart

Ileum, mucosa

Kidney, cortex

Kidney, medulla

Liver

Lung

Ovary, stroma

Pancreas

Parathyroid

Parotid gland – Cytokeratin 5 is expressed in myoepithelial cells and basal cells of excretion ducts of salivary glands.

Pituitary gland, anterior lobe

Pituitary gland, posterior lobe

Pregnant uterus (decidua)

Placenta, early

Placenta, mature

Prostate – Basal cells of the prostatic glands show strong KRT5 immunostaining.

Rectum, mucosa

Seminal vesicle

Sinus paranasales – Cytokeratin 5 is expressed in basal cells of respiratory epithelium as well as in myoepithelial cells of associated glands.

Skin – In the skin, CK5 staining predominantly occurs in the basal 50% of the epidermis, while the upper half stains weaker or can be completely negative.

Spleen

Stomach, antrum

Stomach, corpus

Stomach, muscular wall

Striated muscle

Testis

Thymus – All epithelial cells and corpuscles of Hassall’s of the thymus stain KRT5 positive.

Thyroid gland

Tonsil – All epithelial cells of tonsil crypts stain KRT5 positive.

Tonsil, surface epithelium – Squamous epithelium of the tonsil surface shows strong cytokeratin 5 immunostaining of all cell layers.

Urinary bladder, muscular wall

Urinary bladder, urothelium – Strong KRT5 staining of basal cells.

Uterus, myometrium