Adrenal gland
Adrenal gland Aorta, media
Aorta, media Appendix, mucosa – All epithelial cells are KRT18 positive.
Appendix, mucosa - All epithelial cells are KRT18 positive.Appendix, muscular wall
Appendix, muscular wall Bone marrow
Bone marrow Breast – Luminal cells but not myoepithelial cells stain CK18 positive in normal breast.
Breast - Luminal cells but not myoepithelial cells stain CK18 positive in normal breast.
Bronchus, mucosa
Bronchus, mucosa Cerebellum (molecular layer, Purkinje cell layer, granule cell layer, white matter)
Cerebellum (molecular layer, Purkinje cell layer, granule cell layer, white matter)Cerebellum (white matter)
Cerebellum (white matter)Cerebrum, grey matter
Cerebrum, grey matterCerebrum, white matter
Cerebrum, white matterColon descendens, mucosa – All epithelial cells are KRT18 positive.
Colon descendens, mucosa - All epithelial cells are KRT18 positive.Colon descendens, muscular wall
Colon descendens, muscular wall Duodenum, Brunner gland – Weak KRT18 staining of Brunner glands.
Duodenum, Brunner gland - Weak KRT18 staining of Brunner glands.Duodenum, mucosa
Duodenum, mucosa Ektocervix
EktocervixEndocervix – Strong KRT18 staining of all epithelial cells.
Endocervix - Strong KRT18 staining of all epithelial cells.Endometrium, proliferation
Endometrium, proliferation Endometrium, secretion
Endometrium, secretion Epididymis – All epithelial cells are KRT18 positive.
Epididymis - All epithelial cells are KRT18 positive.Esophagus, squamous epithelium
Esophagus, squamous epithelium Fallopian tube, mucosa
Fallopian tube, mucosa Fat
FatGallbladder, epithelium
Gallbladder, epithelium Heart
HeartIleum, mucosa – All epithelial cells are KRT18 positive.
Ileum, mucosa - All epithelial cells are KRT18 positive.Kidney, cortex
Kidney, cortex Kidney, medulla
Kidney, medulla Kidney, pelvis, urothelium – The urothelium shows the strongest KRT18 staining in umbrella cells. Staining intensity decreases gradually from the top to the bottom layers of the urothelium.
Kidney, pelvis, urothelium - The urothelium shows the strongest KRT18 staining in umbrella cells. Staining intensity decreases gradually from the top to the bottom layers of the urothelium.
Liver – Liver tissue shows a zonal variability of KRT18 expression in hepatocytes ranging from weak to strongly positive while bile ducts are always strongly positive.
Liver - Liver tissue shows a zonal variability of KRT18 expression in hepatocytes ranging from weak to strongly positive while bile ducts are always strongly positive.
Liver – Not all hepatocytes stain positive for CK18 (zonal distribution).
Liver - Not all hepatocytes stain positive for CK18 (zonal distribution).
Lung
LungLymph node – A delicate KRT18 staining occurs in fibroblastic reticulum cells of lymphoid organs.
Lymph node - A delicate KRT18 staining occurs in fibroblastic reticulum cells of lymphoid organs.
Ovary, stroma
Ovary, stroma Pancreas
PancreasParathyroid
ParathyroidParotid gland
Parotid gland Pituitary, anterior lobe
Pituitary gland, anterior lobe Pituitary gland, posterior lobe
Pituitary gland, posterior lobePregnant uterus (decidua)
Pregnant uterus (decidua) Placenta, early
Placenta, early Placenta, mature
Placenta, mature Placenta (amnion and chorion) – Strong CK18 staining in chorion cells while the amnion cells are only weakly CK18 positive.
Placenta (amnion and chorion) - Strong CK18 staining in chorion cells while the amnion cells are only weakly CK18 positive.
Prostate
ProstateRectum, mucosa
Rectum, mucosa Seminal vesicle
Seminal vesicle Sinus paranasales
Sinus paranasales Skin
SkinSpleen
SpleenStomach, antrum – Strong KRT18 staining of all epithelial cells.
Stomach, antrum - Strong KRT18 staining of all epithelial cells.Stomach, corpus
Stomach, corpus Striated muscle
Striated muscle Testis
TestisThymus – Some elements (few cells) of Hassal bodies are CK18 positive.
Thymus - Some elements (few cells) of Hassal bodies are CK18 positive.Thymus
ThymusThyroid gland
Thyroid gland Tonsil, surface epithelium
Tonsil, surface epithelium Urinary bladder, muscular wall
Urinary bladder, muscular wall Urinary bladder, urothelium – Urothelium with particularly strong staining in umbrella cells. CK18 staining is weaker in urothelial cells and gradually decreases from the top to the bottom layers.
Urinary bladder, urothelium - Urothelium with particularly strong staining in umbrella cells. CK18 staining is weaker in urothelial cells and gradually decreases from the top to the bottom layers.
Uterus, myometrium
Uterus, myometrium