Normal Tissue Gallery Cytokeratin 14

Adrenal gland

Aorta, media

Appendix, mucosa

Appendix, muscular wall

Bone marrow

Breast – A variable cytokeratin 14 immunostaining is seen in luminal cells of glands and excretory ducts of the breast gland.

Bronchus, mucosa

Cerebellum, cortex (Stratum moleculare)

Cerebellum, grey (Stratum neuronorum)

Cerebrum, grey matter

Cerebrum, white matter

Cerebrum, white matter

Colon descendens, mucosa

Colon descendens, muscular wall

Duodenum, Brunner gland

Duodenum, mucosa

Ectocervix – KRT14 staining occurs in all layers of non-keratinizing squamous epithelium, but superficial layers stain sometimes slightly weaker.

Endocervix

Endometrium, proliferation

Endometrium, secretion

Epididymis

Esophagus, squamous epithelium – KRT14 staining occurs in all layers of non-keratinizing squamous epithelium, but staining can be weaker or absent in superficial layers.

Fallopian tube, mucosa

Fat

Gallbladder, epithelium

Heart

Ileum, mucosa

Kidney, cortex – A faint KRT14 staining in glomeruli may represent a (tolerable) cross-reactivity of the antibody.

Kidney, cortex – Faint KRT14 staining in glomeruli may represent a (tolerable) cross-reactivity of the antibody.

Kidney, medulla

Liver

Lung

Lymph node

Ovary, stroma

Pancreas

Parathyroid

Parotid gland – In salivary glands, cytokeratin 14 is expressed in myoepithelial cells as well as in basal cells and a fraction of ductal cells of excretory ducts.

Pituitary gland, posterior lobe

Placenta early, decidua

Placenta, early

Placenta (amnion and chorion) – A moderate to strong KRT14 staining occurs in amnion cells and cytotrophoblast cells of the placenta.

Placenta, mature

Prostate – Cytokeratin 14 is strongly expressed in basal cells of the prostate.

Rectum, mucosa

Seminal vesicle

Sinus paranasales – Strong cytokeratin 14 immunostaining occurs in basal cells of the respiratory epithelium.

Skin

Spleen

Stomach, antrum

Stomach, corpus

Striated muscle

Testis

Thymus – All epithelial cells and corpuscles of Hassall’s stain KRT14 positive.

Thyroid gland

Tonsil – Squamous epithelium of the tonsil surface shows strong cytokeratin 14 immunostaining of all cell layers. Lymphocytes remain negative.

Tonsil, surface epithelium – Squamous epithelium of the tonsil surface shows strong cytokeratin 14 immunostaining of all cell layers.

Urinary bladder, muscular wall

Urinary bladder, urothelium – KRT14 is absent in urothelium.

Uterus, myometrium