Normal Tissue Gallery CTLA-4 / CD152

Adrenal gland – Strong granular cytoplasmic CTLA-4 immunostaining of adrenocortical cells (tolerable cross-reactivity). Staining is absent in medullary cells.

Adrenal gland – Weak to moderate granular cytoplasmic CTLA-4 immunostaining of adrenocortical cells (tolerable cross-reactivity).

Aorta, media

Appendix, mucosa – Distinct CTLA-4 immunostaining in a fraction of lymphocytes. In addition, weak apical cytoplasmic granular CTLA-4 staining occurs in superficial epithelial cells (tolerable cross-reactivity)

Appendix, muscular wall

Bone marrow

Breast

Bronchus, mucosa

Cerebellum (molecular layer, Purkinje cell layer, granule cell layer, white matter) – Faint fibrillar CTLA-4 immunostaining of the molecular layer (tolerable cross-reactivity).

Cerebellum (molecular layer, Purkinje cell layer, granule cell layer) – A faint fibrillar CTLA-4 immunostaining of the molecular layer may reflect a (tolerable) cross-reactivity.

Cerebrum, grey matter

Cerebrum, white matter

Colon descendens, mucosa – Weak apical cytoplasmic granular CTLA-4 immunostaining in superficial epithelial cells (tolerable cross-reactivity).

Colon descendens, muscular wall

Duodenum, Brunner gland

Duodenum, mucosa – Apical cytoplasmic granular CTLA-4 positivity in superficial epithelial cells (tolerable cross-reactivity).

Epididymis – Weak apical cytoplasmic granular CTLA-4 immunostaining in tall columnar cells of the epididymis (tolerable cross-reactivity).

Esophagus, squamous epithelium

Fallopian tube, mucosa

Fat

Gallbladder, epithelium – Weak apical cytoplasmic granular CTLA-4 immunostaining in epithelial cells (tolerable cross-reactivity).

Heart muscle

Ileum, mucosa – Weak apical cytoplasmic granular CTLA-4 immunostaining in superficial epithelial cells of the stomach (tolerable cross-reactivity).

Kidney, cortex – Granular CTLA-4 staining in a small fraction of renal tubuli (tolerable cross-reactivity).

Kidney, cortex

Kidney, medulla

Liver – Weak granular CTLA-4 staining of pigment.

Lung

Lymph node – CTLA-4 immunostaining in a fraction of lymphocytes.

Ovary, stroma

Pancreas – Weak apical cytoplasmic granular CTLA-4 staining in acinar cells and in excretory duct epithelial cells (tolerable cross-reactivity).

Pancreas

Parathyroid gland

Parotid gland

Pituitary gland, anterior lobe

Pituitary gland, posterior lobe

Placenta (amnion and chorion)

Placenta, early

Placenta, mature

Prostate

Rectum, mucosa

Seminal vesicle

Sinus paranasales – A fraction of mucosa associated lymphocytes shows distinct CTLA-4 positivity.

Skeletal muscle

Skin

Spleen – CTLA-4 immunostaining in a fraction of lymphocytes.

Stomach, antrum – Apical cytoplasmic granular CTLA-4 immunostaining in superficial epithelial cells of the stomach (tolerable cross-reactivity).

Stomach, corpus – Weak apical cytoplasmic granular CTLA-4 immunostaining in some superficial epithelial cells of the stomach (tolerable cross-reactivity).

Testis

Thymus – CTLA-4 positivity in a fraction of lymphocytes.

Thymus – CTLA-4 staining in a fraction of lymphocytes.

Thyroid gland – CTLA-4 immunostaining of kolloid. This may represent a (tolerable) cross-reactivity.

Tonsil – A distinct CTLA-4 immunostaining is seen in a fraction of lymphocytes.

Tonsil – CTLA-4 immunostaining of a subset of lymphocytes (predominantly interfollicular).

Tonsil – Distinct CTLA-4 positivity in a fraction of lymphocytes.

Tonsil, surface epithelium – Distinct staining of a subset of lymphocytes.

Urinary bladder, muscular wall

Urinary bladder, urothelium – CTLA-4 positivity of a subset of mucosa associated lymphocytes.

Urinary bladder, urothelium

Uterus, ectocervix

Uterus, endocervix

Uterus, endometrium (pregnancy) – Granular cytoplasmic CTLA-4 immunostaining of decidua cells (tolerable cross-reactivity).

Uterus, endometrium (proliferation)

Uterus, endometrium (secretion)

Uterus, myometrium