Adrenal gland - Strong granular cytoplasmic CTLA-4 immunostaining of adrenocortical cells (tolerable cross-reactivity). Staining is absent in medullary cells.
Adrenal gland - Weak to moderate granular cytoplasmic CTLA-4 immunostaining of adrenocortical cells (tolerable cross-reactivity).
Aorta, media
Appendix, mucosa - Distinct CTLA-4 immunostaining in a fraction of lymphocytes. In addition, weak apical cytoplasmic granular CTLA-4 staining occurs in superficial epithelial cells (tolerable cross-reactivity)
Appendix, muscular wall
Bone marrow
Breast
Bronchus, mucosa
Cerebellum (molecular layer, Purkinje cell layer, granule cell layer, white matter) - Faint fibrillar CTLA-4 immunostaining of the molecular layer (tolerable cross-reactivity).
Cerebellum (molecular layer, Purkinje cell layer, granule cell layer) - A faint fibrillar CTLA-4 immunostaining of the molecular layer may reflect a (tolerable) cross-reactivity.
Cerebrum, grey matter
Cerebrum, white matter
Colon descendens, mucosa - Weak apical cytoplasmic granular CTLA-4 immunostaining in superficial epithelial cells (tolerable cross-reactivity).
Colon descendens, muscular wall
Duodenum, Brunner gland
Duodenum, mucosa - Apical cytoplasmic granular CTLA-4 positivity in superficial epithelial cells (tolerable cross-reactivity).
Epididymis - Weak apical cytoplasmic granular CTLA-4 immunostaining in tall columnar cells of the epididymis (tolerable cross-reactivity).
Esophagus, squamous epithelium
Fallopian tube, mucosa
Fat
Gallbladder, epithelium - Weak apical cytoplasmic granular CTLA-4 immunostaining in epithelial cells (tolerable cross-reactivity).
Heart muscle
Ileum, mucosa - Weak apical cytoplasmic granular CTLA-4 immunostaining in superficial epithelial cells of the stomach (tolerable cross-reactivity).
Kidney, cortex - Granular CTLA-4 staining in a small fraction of renal tubuli (tolerable cross-reactivity).
Kidney, cortex
Kidney, medulla
Liver - Weak granular CTLA-4 staining of pigment.
Lung
Lymph node - CTLA-4 immunostaining in a fraction of lymphocytes.
Ovary, stroma
Pancreas - Weak apical cytoplasmic granular CTLA-4 staining in acinar cells and in excretory duct epithelial cells (tolerable cross-reactivity).
Pancreas
Parathyroid gland
Parotid gland
Pituitary gland, anterior lobe
Pituitary gland, posterior lobe
Placenta (amnion and chorion)
Placenta, early
Placenta, mature
Prostate
Rectum, mucosa
Seminal vesicle
Sinus paranasales - A fraction of mucosa associated lymphocytes shows distinct CTLA-4 positivity.
Skeletal muscle
Skin
Spleen - CTLA-4 immunostaining in a fraction of lymphocytes.
Stomach, antrum - Apical cytoplasmic granular CTLA-4 immunostaining in superficial epithelial cells of the stomach (tolerable cross-reactivity).
Stomach, corpus - Weak apical cytoplasmic granular CTLA-4 immunostaining in some superficial epithelial cells of the stomach (tolerable cross-reactivity).
Testis
Thymus - CTLA-4 positivity in a fraction of lymphocytes.
Thymus - CTLA-4 staining in a fraction of lymphocytes.
Thyroid gland - CTLA-4 immunostaining of kolloid. This may represent a (tolerable) cross-reactivity.
Tonsil - A distinct CTLA-4 immunostaining is seen in a fraction of lymphocytes.
Tonsil - CTLA-4 immunostaining of a subset of lymphocytes (predominantly interfollicular).
Tonsil - Distinct CTLA-4 positivity in a fraction of lymphocytes.
Tonsil, surface epithelium - Distinct staining of a subset of lymphocytes.
Urinary bladder, muscular wall
Urinary bladder, urothelium - CTLA-4 positivity of a subset of mucosa associated lymphocytes.
Urinary bladder, urothelium
Uterus, ectocervix
Uterus, endocervix
Uterus, endometrium (pregnancy) - Granular cytoplasmic CTLA-4 immunostaining of decidua cells (tolerable cross-reactivity).
Uterus, endometrium (proliferation)
Uterus, endometrium (secretion)
Uterus, myometrium