Breast- Invasive breast cancer of no special type (NST) with strong Trop-2 immunostaining of tumor cells.
Breast- Invasive lobular breast cancer with weak to moderate Trop-2 immunostaining of tumor cells. Note: Trop-2 staining is more intense in a normal breast gland.
Colon- Colorectal adenocarcinoma with a weak to moderate Trop-2 immunostaining in few tumor cells.
Esophagus- Adenocarcinoma with strong Trop-2 immunostaining of tumor cells.
Esophagus- Squamous cell carcinoma showing a strong, predominantly membranous Trop-2 tumor cell positivity.
Kidney- Chromophobe renal cell carcinoma exhibiting a strong membranous Trop-2 staining of tumor cells.
Kidney- Intense, predominantly membranous Trop-2 positivity of tumor cells in a papillary renal cell carcinoma.
Kidney- Trop-2 negative clear cell renal cell carcinoma.
Liver- Trop-2 negative hepatocellularcellular carcinoma.
Lung- Adenocarcinoma with strong membranous Trop-2 staining of tumor cells.
Lung- Malignant mesothelioma with moderate membranous Trop-2 immunostaining in a small fraction of tumor cells.
Lung- Squamous cell carcinoma with strong Trop-2 immunostaining of tumor cells.
Lung- Trop-2 negative malignant mesothelioma (epitheloid).
Ovary- Endometroid carcinoma with strong Trop-2 positivity in 70% of tumor cells.
Ovary- Serous high-grade carcinoma with strong Trop-2 immunostaining of >90% of tumor cells. A few intermingled tumor cells show much weaker positivity.
Ovary- Serous high-grade carcinoma with strong, predominantly membranous Trop-2 immunostaining of tumor cells.
Pancreas- Trop-2 negative neuroendocrine tumor.
Prostate- Adenocarcinoma (Gleason 3+3=6) with strong Trop-2 immunostaining of tumor cells.
Salivary gland- Warthin tumor with intense predominantly membranous Trop-2 staining of tumor cells.
Stomach- Gastric adenocarcinoma (diffuse type) with weak to moderate Trop-2 immunostaining of most tumor cells.
Stomach- Gastric adenocarcinoma with weak to moderate membranous Trop-2 immunostaining of a small fraction of tumor cells.
Stomach- Trop-2 negative gastrointestinal stromal tumor (GIST).
Testis- Trop-2 negative Leydig cell tumor.
Testis- Trop-2 negative seminoma.
Thyroid- Papillary cancer with strong Trop-2 positivity of tumor cells.
Thyroid- Trop-2 negative medullary carcinoma.
Urinary bladder- Muscle-invasive urothelial carcinoma showing a strong Trop-2 positivity of tumor cells.
Vulva- Squamous cell carcinoma showing strong Trop-2 immunostaining.