Adrenal gland – Nectin-4 negative adrenocortical adenoma.
Breast – Invasive breast cancer of no special type (NST) with moderate membranous Nectin-4 staining of tumor cells.
Breast – Invasive lobular breast cancer with strong membranous nectin-4 immunostaining of tumor cells.
Breast – Nectin-4 negative invasive breast cancer of no special type (NST).
Colon – Nectin-4 negative colorectal adenocarcinoma.
Esophagus – Adenocarcinoma with faint membranous (luminal membranes) nectin-4 immunostaining of many tumor cells.
Esophagus – Squamous cell carcinoma with weak to moderate membranous nectin-4 positivity of a small fraction of tumor cells.
Kidney – Nectin-4 negative clear cell carcinoma.
Kidney – Nectin-4 negative papillary renal cell carcinoma.
Lung – Adenocarcinoma with focal strong membranous nectin-4 positivity of tumor cells.
Lung – Adenocarcinoma with weak to moderate, membranous, predominantly basolateral nectin-4 staining of most tumor cells.
Lung – Squamous cell carcinoma with weak to moderate membranous nectin-4 staining of tumor cells.
Oral cavity – Squamous cell carcinoma with moderate to strong membranous nectin-4 staining of tumor cells.
Ovary – Endometroid carcinoma with moderate to strong, membranous nectin-4 positivity of most tumor cells.
Ovary – Serous high-grade carcinoma with distinct membranous nectin-4 staining of most tumor cells.
Pancreas – Nectin-4 negative ductal adenocarcinoma.
Penis – Squamous cell carcinoma with intense membranous nectin-4 positivity of all tumor cells. .jpeg
Prostate – Nectin-4 negative adenocarcinoma (Gleason 3+3=6).
Prostate – Nectin-4 negative adenocarcinoma (Gleason 5+5=10).
Testis – Nectin-4 negative embryonal carcinoma. .jpeg
Testis – Nectin-4 negative seminoma. .jpeg
Urinary bladder – Muscle-invasive urothelial carcinoma with moderate to strong membranous nectin-4 positivity of tumor cells.
Urinary bladder – Muscle-invasive urothelial carcinoma with strong membranous nectin-4 positivity of about 50_ of tumor cells.
Urinary bladder – Non-invasive urothelial carcinoma (low grade, pTaG2) with moderate to strong membranous nectin-4 positivity of all tumor cells.
Uterus, cervix – Squamous cell carcinoma with faint membranous Nectin-4 immunostaining of some tumor cells.
Vulva – Squamous cell carcinoma with strong membranous nectin-4 immunostaining of tumor cells.