Adrenal gland - A variable MCM2 staining occurs in a small fraction of adrenocortical cells
Aorta, media
Appendix, mucosa - MCM2 staining predominates in in epithelial cells of the crypts. Some lymphocytes are also positive
Appendix, muscular wall – Faint MCM2 staining in some muscle cells
Bone marrow - Moderate to strong MCM2 staining in most bone marrow cells
Breast - Strong MCM2 staining of almost all luminal cells
Bronchus, mucosa - Significant MCM2 staining in a fraction of (mostly basal-suprabasal) respiratory epithelial cells
Cerebellum, cortex (Stratum moleculare)
Cerebellum, grey (Stratum neuronorum)
Cerebrum, grey
Cerebrum, white
Colon descendens, mucosa - MCM2 staining predominates in epithelial cells of the crypts
Colon descendens, muscular wall - Faint MCM2 staining in some muscle cells
Duodenum, Brunner gland - Weak MCM2 staining in a fraction of epithelial cells
Duodenum, mucosa - MCM2 staining predominates in epithelial cells of the crypts
Epididymis - Significant MCM2 staining in a fraction of epithelial cells
Esophagus, squamous epithelium - Esophageal squamous epithelium shows a moderate to strong MCM2 staining of suprabasal and basal cells
Fallopian tube, mucosa - Strong MCM2 staining of a significant subset of epithelial cells
Fat
Gallbladder, epithelium - A variable number of MCM2 positive cells can be seen in the gallbladder epithelium
Heart muscle – Faint MCM2 staining in some muscle cells
Ileum, mucosa - MCM2 staining predominates in epithelial cells of the crypts
Kidney, cortex - Few epithelial cells are MCM2 positive
Kidney, medulla - Significant MCM2 staining in a fraction of collecting duct cells
Liver - MCM2 staining of variable intensity in a small fraction of hepatocytes
Lung - Strong MCM2 staining of a large subset of pneumocytes
Lymph node - Many lymphocytes are MCM2 positive. Strongest MCM2 staining occurs in most cells of germinal centres and in scattered individual cells of the interfollicular zone
Ovary (corpus luteum) - Weak MCM2 staining of corpus luteum cells
Ovary (follicular cyst) - Strong MCM2 staining of a large fraction of granulosa and theca interna cells
Ovary, stroma - Weak to moderate MCM2 staining of stroma cells
Pancreas - Moderate to strong MCM2 staining in a small fraction of pancreatic epithelial cells
Parathyroid gland - MCM2 staining in a small fraction of epithelial cells
Parotid gland - Weak to moderate MCM2 staining in a fraction of epithelial cells
Pituitary, posterior lobe- infundibulum - Weak MCM2 staining in a small fraction of cells
Pituitary, posterior lobe- infundibulum - Weak MCM2 staining in a small fraction of epithelial cells
Placenta (amnion) - Absence of MCM2 staining in amnion cells
Placenta (chorion) - Moderate to strong MCM2 staining in a fraction of chorion cells
Placenta, early - Strong MCM2 staining of a large fraction of cytotrophoblast cells
Placenta, mature - Strong MCM2 staining of a fraction of cytotrophoblast cells
Prostate - MCM2 staining is more common in basal than in acinar epithelial cells
Rectum, mucosa - The strongest MCM2 staining occurs in the deepest epithelial cells of the crypts
Seminal vesicle - MCM2 staining of variable intensity in a fraction of epithelial cells
Sinus paranasales - Significant MCM2 staining in a fraction of (mostly suprabasal) respiratory epithelial cells
Skeletal muscle – Significant MCM2 staining in a large fraction of skeletal muscle cells
Skin - Suprabasal and basal cell layers (weaker) of the squamous epithelium show a distinct MCM2 positivity
Skin, hairfollicel and sebaceous glands - Intense MCM2 positivity of peripheral germinative cells
Spleen - A strong MCM2 positivity occurs in scattered cells of all compartments
Stomach, antrum - Strong MCM2 immunostaining in many mucous neck cells
Stomach, corpus - Strong MCM2 immunostaining in many mucous neck cells
Sublingual gland - Weak MCM2 staining in a fraction of epithelial cells
Testis - Most spermatogonia and spermatocytes show strong MCM2 positivity
Thymus - Strong MCM2 positivity of most cells of the thymic cortex
Thyroid gland - Weak to moderate MCM2 staining of a small fraction of follicular cells
Tonsil - A large fraction of lymphocytes is at least weakly MCM2 positive. In the tonsil crypts, many epithelial cells (basal-suprabasal) are MCM2 positive
Tonsil - Many lymphocytes are MCM2 positive. Strongest MCM2 staining occurs in most cells of germinal centres and in scattered individual cells of the interfollicular zone
Urinary bladder, muscular wall - Faint MCM2 staining in some muscle cells
Urinary bladder, urothelium - Some (suprabasal) urothelial cells show a MCM2 staining
Uterus, ectocervix - The squamous epithelium shows a moderate MCM2 immunostaining of (mostly) suprabasal cells
Uterus, endocervix - Only few epithelial cells show MCM2 staining
Uterus, endometrium (pregnancy)
Uterus, endometrium (proliferation) - Almost all epithelial cells and a fraction of stromal cells are MCM2 positive
Uterus, endometrium (secretion) - The fraction of MCM2 positive epithelial cells is lower in the secretion phase
Uterus, myometrium – Weak MCM2 staining in some muscle cells