Normal Tissue Gallery TRPS1

Adrenal gland

Anal canal, skin – Weak nuclear TRPS1 staining ina fraction of suprabasal squamous epithelial cells

Aorta, media

Appendix, mucosa – Some nuclear TRPS1 staining in stromal cells

Bone marrow

Breast – Intense nuclear TRPS1 staining of luminal (but not basal) epithelial cells

Bronchus, mucosa – Weak to moderate nuclear TRPS1 staining of a fraction of respiratory epithelial cells, mostly basal and of squamous metaplasia

Cerebellum (molecular layer, Purkinje cell layer, granule cell layer, white matter)

Cerebellum, cortex (Stratum moleculare)

Cerebrum, grey – Strong nuclear TRPS1 staining of glia cells

Cerebrum, white

Colon descendens, mucosa – Some nuclear TRPS1 staining in stromal cells

Colon descendens, muscular wall – Weak nuclear TRPS1 staining in smooth muscle cells and in ganglion cells

Duodenum, Brunner gland

Duodenum, mucosa – Some nuclear TRPS1 staining in stromal cells

Epididymis – Very faint nuclear TRPS1 staining in some epithelial cells

Esophagus, squamous epithelium – Weak nuclear TRPS1 staining of suprabasal squamous epithelial cells

Fallopian tube, mucosa –Weak nuclear TRPS1 staining of a fraction of epithelial cells

Fat

Gallbladder, epithelium – Faint nuclear TRPS1 staining in epithelial cells

Heart muscle – Moderate nuclear TRPS1 staining of a fraction of stroma cells

Ileum, mucosa

Kidney, cortex – Weak nuclear TRPS1 staining in a fraction of cells in tubuli

Kidney, medulla – Weak nuclear TRPS1 staining in a fraction of cells of collecting ducts

Liver

Liver

Lung

Lymph node

Ovary, stroma

Pancreas – TRPS1 staining is lacking in this sample

Pancreas – Weak nuclear TRPS1 staining in stroma cells

Parathyroid gland – Weak to moderate nuclear TRPS1 staining of epithelial cells

Parotid gland – Faint nuclear TRPS1 staining in some epithelial cells

Pituitary, anterior lobe – Faint nuclear TRPS1 staining of a fraction of epithelial cells

Pituitary, posterior lobe- infundibulum

Placenta (amnion and chorion) – amnion and chorion cells are TRPS1 negative in most instances

Placenta (amnion) – A weak nuclear TRPS1 staining is rarely seen in few amnion cells

Placenta, early

Placenta, mature

Prostate – Variable (faint to moderate) nuclear TRPS1 staining in acinar cells. Probably depending on functional status. Weak to moderate staining of (muscular) stroma cells

Rectum, mucosa – Some nuclear TRPS1 staining in stromal cells

Seminal vesicle – Weak nuclear TRPS1 staining in muscular stroma cells

Sinus paranasales – Weak to moderate nuclear TRPS1 staining of a fraction of respiratory epithelial cells and of some stroma cells

Skin – Weak nuclear TRPS1 staining in suprabasal squamous epithelial cells (not in all samples)

Skin, hairfollicel and sebaceous glands – Moderate to strong nuclear TRPS1 staining of sebaceous gland cells and in epithelial cells of hair follicles

Spleen

Stomach, antrum

Striated muscle

Submandibular gland – Weak nuclear TRPS1 staining in glandular (serous and mucinous) and excretory duct cells

Testis – Weak nuclear TRPS1 staining in spermatogonia

Thymus

Thyroid gland – Faint nuclear TRPS1 staining of a fraction of epithelial cells

Tonsil, surface epithelium – Weak to moderate nuclear TRPS1 staining in most squamous epithelial cells

Tonsil

Urinary bladder, muscular wall

Urinary bladder, urothelium – Weak nuclear TRPS1 staining in a fraction of urothelial cells

Uterus, ectocervix – Moderate nuclear TRPS1 staining of suprabasal squamous epithelial cells

Uterus, endocervix – Endocervical epithelial cells are usually TRPS1 negative (but can be TRPS1 positive in case of “stressed” epithelium”)

Uterus, endometrium (pregnancy) – Weak nuclear TRPS1 staining of epithelial cells

Uterus, endometrium (proliferation) – Moderate nuclear TRPS1 staining of epithelial cells and weak staining of stroma cells

Uterus, endometrium (secretion) – Weak nuclear TRPS1 staining of epithelial cells

Uterus, myometrium – Weak nuclear TRPS1 staining in a fraction of muscular cells