Normal Tissue Gallery SOX9

Adrenal gland – Few interspersed cells in the cortex showing weak to moderate SOX9 positivity

Aorta, media

Appendix, mucosa – Strong nuclear SOX9 staining of crypt epithelial cells, especially at the base. SOX9 staining intensity gradually decreases towards the surface. The surface epithelium remains SOX9 negative (or shows only a very weak staining).

Appendix, muscular wall

Bone marrow

Breast – Epithelial cells are largely SOX9 negative or may show faint staining

Bronchus, mucosa – Moderate to strong SOX9 positivity of most epithelial cells

Cerebellum, cortex (Stratum moleculare) – 2

Cerebellum, cortex (Stratum moleculare)

Cerebrum, grey

Cerebrum, white

Colon descendens, mucosa – Strong nuclear SOX9 staining of crypt epithelial cells, especially at the base. SOX9 staining intensity gradually decreases towards the surface. The surface epithelium remains SOX9 negative (or shows only a very weak staining).

Colon descendens, muscular wall

Duodenum, Brunner gland – Strong SOX9 staining of Brunner gland cells

Duodenum, mucosa – Strong nuclear SOX9 staining of crypt epithelial cells. The SOX9 staining intensity markedly decreases towards the surface epithelium and the tips of the villosities remain SOX9 negative.

Endometrium, secretion – Strong SOX9 positivity of epithelial cells. Stroma cells are SOX9 negative

Epididymis – Weak to moderate nuclear SOX9 staining of basal cells in the caput

Esophagus, squamous epithelium – Weak to moderate nuclear SOX9 staining of the bottom 2-3 of squamous epithelium

Fallopian tube, mucosa – Moderate to strong SOX9 staining of a large subset of epithelial cells

Fat

Gallbladder, epithelium

Heart

Ileum, mucosa – Strong nuclear SOX9 staining of crypt epithelial cells, especially at the base. SOX9 staining intensity gradually decreases towards the surface. The surface epithelium remains SOX9 negative (or shows only a very weak staining).

Kidney, cortex – Few cells of the tubuli may show a weak to moderate SOX9 staining

Kidney, medulla – Moderate to strong SOX9 staining of a subset of collecting duct cells

Liver – Moderate to strong nuclear SOX9 staining of intrahepatic bile ducts

Lung

Lymph node – Weak to moderate nuclear SOX9 positivity of a fraction of cells in germinal centres

Ovary, stroma

Pancreas – Strong nuclear SOX9 staining of intercalated and excretory ducts, while acinar cells are less often positive and islet cells are SOX9 negative

Parathyroid

Parotid gland – Moderate to strong nuclear SOX9 staining of all epithelial cell types

Pituitary, anterior lobe – Moderate to strong SOX9 staining of a small subset of epithelial cells in the adenohypophysis

Pituitary, anterior lobe – Weak to moderate SOX9 positivity of fibrillar cells in the neurohypophysis

Placenta early, decidua

Placenta, early

Placenta, mature

Placenta, mature, amnion and chorion

Placenta, mature, amnion and chorion (2)

Prostate – Strong SOX9 positivity of basal cells while luminal cells show only a markedly weaker staining

Rectum, mucosa – Strong nuclear SOX9 staining of crypt epithelial cells, especially at the base. SOX9 staining intensity gradually decreases towards the surface. The surface epithelium remains SOX9 negative (or shows only a very weak staining).

Seminal vesicle – Moderate to strong SOX9 positivity of epithelial cells

Sinus paranasales – Moderate to strong SOX9 positivity of most epithelial cells

Skin – Weak to moderate nuclear SOX9 staining of the bottom 2-3 of squamous epithelium

Skin (sebaceous and ekkrine glands) – Strong SOX9 staining of ekkrine glands. Weak to moderate nuclear SOX9 staining of sebaceous glands

Spleen

Stomach, antrum – Moderate to strong nuclear SOX9 staining of surface epithelial cells, while the glandular cells are SOX9 negative

Stomach, corpus – Moderate to strong nuclear SOX9 staining of surface epithelial cells, while the glandular cells only show weak positivity

Striated muscle

Sublingual gland – Moderate to strong nuclear SOX9 staining of all epithelial cell types

Testis – Strong SOX9 staining of Sertoli cells

Thymus

Thyroid gland – Moderate to strong SOX9 positivity of follicular cells

Tonsil – Weak to moderate nuclear SOX9 positivity of a fraction of cells in germinal centres and in a fraction of krypt epithelial cells

Tonsil, surface epithelium – Faint nuclear SOX9 staining of some epithelial cells, mainly in the bottom 2-3 of the squamous epithelium

Urinary bladder, muscular wall

Urinary bladder, urothelium – A weak SOX9 staining can occur in the superficial cell layers (umbrella cells) of the urothelium

Uterus, ectocervix – Weak to moderate nuclear SOX9 staining of the bottom 2-3 of squamous epithelium

Uterus, endocervix – Weak nuclear SOX9 staining of epithelial cells

Uterus, endometrium (proliferation) – Moderate SOX9 positivity of epithelial cells. Stroma cells are SOX9 negative

Uterus, myometrium