Adrenal gland
Anal canal, skin – HMGB1 staining intensity is strongest in the basal and suprabasal cell layers and it countinuously decreases towards the superficial cell layers
Aorta, media
Appendix, mucosa
Appendix, muscular wall
Bone marrow – Intense nuclear HMGB1 staining of virtually all cells of the hematopesis
Breast – HMGB1 positivity is strongest in basal and luminal epithelial cells
Bronchus, mucosa – Significant nuclear HMGB1 staining of all cells. Among epithelia, HMGB1 staining is most intense in basal cells
Cerebellum (white matter)
Cerebellum, cortex (molecular layer, Purkinje cell layer, granule cell layer, white matter)
Cerebrum, grey matter
Cerebrum, white matter
Colon descendens, mucosa – Significant nuclear HMGB1 staining of all cells. Staining intensity is higher in the crypt base than in the surface epithelium
Colon descendens, muscular wall
Duodenum, Brunner gland – Significant nuclear HMGB1 staining of all epithelial and inflammatory cells. HMGB1 staining is somewhat weaker in Brunner glands
Duodenum, mucosa
Epididymis (Cauda)
Epididymis (Corpus) – HMGB1 staining is more intense in basal than in chief cells
Esophagus, squamous epithelium – HMGB1 staining intensity is strongest in the basal and suprabasal cell layers and countinuously decreases towards the superficial cell layers
Fallopian tube, mucosa
Fat
Gallbladder, epithelium
Heart muscle
Ileum, mucosa
Kidney, cortex – Significant nuclear HMGB1 staining of all cells. Staining is particularly low in tubuli (especially proximal) and highest in collecting ducts and glomeruli
Kidney, medulla – Strong nuclear HMGB1 staining of collecting duct cells
Liver – Significant nuclear HMGB1 staining of all cells. Staining is particularly high in bile ducts and particularly low in hepatocytes
Lung
Lymph node
Ovary, corpus luteum – HMGB1 staining is only faint in the corpus luteum
Ovary, stroma
Pancreas
Parathyroid gland
Parotis
Pituitary gland, anterior lobe
Pituitary gland, posterior lobe
Placenta (amnion and chorion) – Strong nuclear HMGB1 staining of chorion cells, moderate nuclear HMGB1 staining of amnion cells
Placenta, early
Placenta, mature
Prostate – Significant nuclear HMGB1 staining of all cells. Staining is particularly low in acinar cells and highest in basal cells
Rectum, mucosa – Significant nuclear HMGB1 staining of all cells. Staining intensity is higher in the crypt base than in the surface epithelium
Seminal vesicle – Significant nuclear HMGB1 staining of all cells. In the epithelium, HMGB1 staining is more intense in basal than in luminal cells
Sinus paranasales – Significant nuclear HMGB1 staining of all cells. Among epithelia, HMGB1 staining is most intense in basal cells
Skeletal muscle
Skin, hairfollicel and sebaceous glands
Spleen
Stomach, antrum
Stomach, corpus (glands)
Stomach, corpus (surface epithelium)
Testis – Significant nuclear HMGB1 staining of Sertoli cells. HMGB1 staining is weaker in the germ cells it where the staining level decreases from spermatogonia to spermatocytes and spermatides (which are HMGB1 negative)
Thymus – Strong nuclear HMGB1 staining of virtually all cells of the immune system. HMBG1 labeling is weaker in corpuscles of Hassall’s, especially in their central areas
Thyroid gland
Tonsil, surface epithelium
Tonsil
Urinary bladder, muscular wall
Urinary bladder, urothelium – Strong nuclear HMGB1 staining of all urothelial cell layers
Uterus, ectocervix – HMGB1 staining intensity is strongest in the basal and suprabasal cell layers and countinuously decreases towards the superficial cell layers
Uterus, endocervix
Uterus, endometrium (pregnancy)
Uterus, endometrium (proliferation) – Strong nuclear HMGB1 staining of epithelial and stromal cells
Uterus, endometrium (secretion) – Strong nuclear HMGB1 staining of stromal cells while HMGB1 staining is markedly less intense in epithelial cells in this sample
Uterus, myometrium