Normal Tissue Gallery Cytokeratin 7

Adrenal gland

Aorta, media

Appendix, mucosa

Appendix, muscular wall

Bone marrow

Breast – Luminal cells show markedly stronger CK7 staining than basal cells.

Bronchus, mucosa – Strong CK7 immunostaining of all cell types except basal cells.

Cerebellum (molecular layer, Purkinje cell layer, granule cell layer)

Cerebellum (granule cell layer, white matter)

Cerebrum, grey matter

Cerebrum, grey matter – Some pigmented cells are seen in this sample. Absence of true CK7 immunostaining.

Cerebrum, white matter

Colon descendens, mucosa

Colon descendens, muscular wall

Duodenum, Brunner gland

Duodenum, mucosa

Ectocervix

Endocervix

Endometrium, proliferation – The CK7 findings are variable in the endometrium: Not all glands show CK7 positivity.

Endometrium, secretion – The CK7 findings are variable in the endometrium. In this sample, all epithelial cells show a strong CK7 positivity.

Endometrium, secretion – The CK7 findings are variable in the endometrium. In this sample, a fraction epithelial cells shows a strong CK7 positivity while others are completely negative.

Epididymis

Esophagus, squamous epithelium

Esophagus, squamous epithelium 2

Fallopian tube, mucosa – All epithelial cells but ciliated cells stain CK7 positive in the fallopian tube.

Fat

Gallbladder, epithelium

Heart

Ileum, mucosa

Kiidney, cortex – CK 7 staining is seen in collecting ducts and in scattered epithelial cells of the visceral layer of the Bowman capsule.

Kidney, medulla – Strong CK 7 staining is seen in collecting ducts.

Liver

Lung – Moderate CK7 positivity of pneumocytes.

Lymph node

Ovary, stroma

Pancreas – Strong CK7 immunostaining of centroacinar cells of small intercalated ducts in the pancreas. A much weaker memranous and cytoplasmic staining of acinar cells can regionally be seen in some cases.

Pancreas – Strong CK7 immunostaining of centroacinar cells of small intercalated ducts in the pancreas.

Parathyroid – Few cells in the parathyroid glands show moderate intensity CK7 immunostaining.

Parotid gland

Pituitary gland, anterior lobe – CK7 immunostaining is not seen in this adenohypophysis sample.

Pituitary, anterior lobe – Few CK7 cells can be seen in the adenohypophysis in some cases.

Pituitary gland, posterior lobe

Pregnant uterus (decidua)

Placenta, early

Placenta, mature

Placenta (amnion and chorion)

Prostate – CK7 immunostaining is completely absent in this sample.

Prostate – A focal CK7 positivity of acinar cells is seen in this sample while staining is absent in basal cells.

Prostate – A moderate to strong CK7 immunostaining of both acinar and basal cells can be seen in this sample.

Rectum, mucosa

Seminal vesicle

Sinus paranasales – Strong CK7 immunostaining of ciliated and goblet cells. Basal cells exhibit only a weak staining.

Skin

Spleen

Stomach, antrum

Stomach, corpus

Striated muscle

Testis – CK7 immunostaining is negative.

Thymus – Weak CK7 immunostaining of some elements of corpuscles of Hassall’s.

Thyroid gland

Tonsil – A small fraction of squamous epithelial cells of the crypts show a moderate to strong CK7 immunostaining.

Tonsil, surface epithelium – Few scattered squamous epithelial cells may stain CK7 positive in the surface epithelium of the tonsil.

Urinary bladder, muscular wall

Urinary bladder, urothelium

Uterus, myometrium