Normal Tissue Gallery CD56

Adrenal gland – Membranous CD56 immunostaining is prominent in the medulla but also occurs – to a lesser degree – in cortical cells.

Aorta, media

Appendix, mucosa – Intense CD56 immunostaining of nerve fibres.

Appendix, muscular wall – Nerve fibres and ganglia show strong CD56 immunostaining.

Bone marrow

Breast

Bronchus, mucosa

Cerebellum (molecular layer, Purkinje cell layer, granule cell layer, white matter) – CD56 immunostaining is particularly strong in neurons, axons and glia cells of the brain.

Cerebellum (molecular layer, Purkinje cell layer, granule cell layer, white matter) – CD56 immunostaining is particularly strong in neurons, axons and glia cells of the brain.

Cerebrum, grey matter – CD56 immunostaining is particularly strong in neurons, axons and glia cells of the brain.

Cerebrum, white matter – CD56 immunostaining is particularly strong in neurons, axons and glia cells of the brain.

Colon descendens, mucosa – Variable intensity CD56 immunostaining of nerve fibres.

Colon descendens, muscular wall – Nerve fibres and ganglia exhibit strong CD56 immunostaining.

Duodenum, Brunner gland – A moderate CD56 immunostaining of basolateral membranes of epithelial cells of Brunner glands can be seen.

Duodenum, mucosa – Nerve fibres stain CD56 positive in the mucosa.

Epididymis – A membranous CD56 immunostaining occurs in the cauda (and not the corpus) epididymis_

Epididymis

Esophagus, squamous epithelium – Scattered CD56 positive lymphocytes can be seen.

Fallopian tube, mucosa

Fat

Gallbladder, epithelium – CD56 immunostaining of nerve fibres.

Heart muscle – CD56 immunostaining of membreans of heart muscle is not seen by other CD56 antibodies and thus considered an (tolerable) cross-reactivity.

Ileum, mucosa – Nerve fibres stain CD56 positive in the mucosa.

Ileum, mucosa – Nerve fibres stain CD56 positive in the mucosa.

Kidney, cortex

Kidney, medulla

Liver – A moderate CD56 staining can occur in small periportal and to a lesser degree in portal bile ducts of the liver.

Liver – A weak to moderate CD56 immunostaining can be seen in cells lining sinusoids.

Lung

Lymph node – Scattered CD56 positive lymphocytes can be seen in lymph nodes.

Ovary, stroma – Stroma cells show a strong membranous CD56 immunostaining.

Pancreas – Few small intraparenchymal ducts and a fraction of the islet cells show weak to moderate membranous CD56 immunostaining.

Parathyroid gland

Parotid gland – Nerve fibres stain CD56 positive.

Pituitary gland, posterior lobe – A strong CD56 immunostaining is seen in the neurohypophysis_

Pituitary, anterior lobe

Placenta (amnion and chorion)

Placenta, early

Placenta, mature

Prostate – Nerve fibres show CD56 immunostaining.

Rectum, mucosa – CD56 positivity of nerve fibres.

Seminal vesicle – Nerve fibres show CD56 immunostaining.

Sinus paranasales – A moderate to strong membranous CD56 immunostaining occurs in a fraction of (non-basal) cells of the respiratory epithelium.

Skeletal muscle – A cytoplasmic staining of skeletal muscle cells can occasionally be seen and is considered a (tolerable) cross-reactivity.

Skeletal muscle

Skin

Somach, antrum – A moderate to strong membranous CD56 immunostaining occurs in most glandular cells of the stomach.

Spleen – Scattered CD56 positive lymphocytes can be seen in the spleen.

Stomach, corpus – A moderate to strong membranous CD56 immunostaining occurs in most glandular cells of the stomach.

Testis – Strong membranous CD56 immunostaining of Leydig cells.

Thymus

Thyroid gland – A strong membranous CD56 immunostaining of follicle cells is seen in the thyroid.

Tonsil – Scattered CD56 positive lymphocytes can be seen in in the tonsil.

Tonsil, surface epithelium

Urinary bladder, muscular wall – A dense net of CD56 positive nerve fibres is seen.

Urinary bladder, urothelium

Uterus, ectocervix

Uterus, endocervix

Uterus, endometrium (pregnancy) – CD56 positive NK-cells are particularly frequent in the endometrium_

Uterus, endometrium (proliferation) – CD56 positive NK-cells regularly occur in the endometrium.

Uterus, endometrium (secretion) – CD56 positive NK-cells are particularly frequent in the endometrium.

Uterus, myometrium – A weak to moderate CD56 immunostaining occurs in muscle fibres of the myometrium