Normal Tissue Gallery Cytokeratin 15

Adrenal gland

Aorta, media

Appendix, mucosa

Appendix, muscular wall

Bone marrow

Breast – A strong KRT15 immunostaining is seen in acinar but not in myoepithelial cells.

Bronchus, mucosa – In the respiratory epithelium, a strong KRT15 immunostaining is seen in basal cells.

Cerebellum (molecular layer, Purkinje cell layer, granule cell layer)

Cerebellum (granule cell layer, white matter)

Cerebrum, grey matter

Cerebrum, white matter

Colon descendens, mucosa

Colon descendens, muscular wall

Duodenum, mucosa

Ectocervix – A strong KRT15 immunostaining is seen in all cell layers of the squamous epithelium.

Endocervix

Endometrium, proliferation

Endometrium, secretion

Epididymis – In the epididymis, a moderate KRT15 immunostaining of basal cells is seen.

Esophagus, squamous epithelium – A strong KRT15 immunostaining is seen in all cell layers of the squamous epithelium.

Fallopian tube, mucosa

Fat

Gallbladder, epithelium

Heart

Ileum, mucosa

Kidney, cortex

Kidney, medulla

Liver – Liver Pigment staining.

Liver

Lung

Lymph node

Ovary, stroma

Pancreas – In the pancreas, a very weak KRT15 immunostaining can be seen in intercalated ducts.

Parathyroid

Parotid gland – A strong KRT15 immunostaining is found in some myoepithelial cells and basal cells of excretiory ducts.

Pituitary gland, anterior lobe – A moderate to strong KRT15 immunostaining can occur in a fraction of epithelial cells in the adenohypophysis.

Pituitary gland, anterior lobe

Pituitary gland, posterior lobe

Pregnant uterus (decidua)

Placenta (amnion and chorion): A variable KRT15 staining is seen in amnion cells.

Placenta, early – A generally weak KRT15 immunostaining can be seen in the syncytiotrophoblast (more common in first trimenon than in mature placenta).

Placenta, early – A weak KRT15 immunostaining can be seen in the syncytiotrophoblast (more common in first trimenon than in mature placenta).

Placenta, mature

Prostate – KRT15 immunostaining is usually strong in all basal cells but can occasionally also occur in luminal epithelial cells.

Rectum, mucosa

Seminal vesicle – In seminal vesicles, only a few basal cells are KRT15 positive.

Sinus paranasales – In the respiratory epithelium, a strong KRT15 immunostaining is seen in basal cells.

Skin – A strong KRT15 immunostaining is seen in all cell layers of the squamous epithelium (except keratin layer).

Spleen

Stomach, antrum

Stomach, corpus – A very faint KRT15 immunostaining can be seen in some gastric glands (apical predominance).

Striated muscle

Testis

Thymus – KRT15 is strongly expressed in corpuscles of Hassall’s and in medullary thymic epithelial cells but weaker in cortical thymic epithelial cells.

Thyroid gland

Tonsil – In tonsil krypts, a strong KRT15 immunostaining is found in all cell layers of squamous epithelium.

Tonsil, surface epithelium – A strong KRT15 immunostaining is seen in all cell layers of the squamous epithelium.

Urinary bladder, muscular wall

Urinary bladder – KRT15 immunostaining is commonly found in urothelium. Staining is often stronger in the basal than in the superficial half of the urothelium.

Uterus, myometrium