Cancer Tissue Gallery CD141

Adrenal gland – CD141 negative adrenocortical adenoma. Staining is limited to endothelial cells (CD141 immunohistochemistry).

Anal canal – Squamous cell carcinoma with strong CD141 immunostaining of tumor cells.

Breast – CD141 negative invasive lobular breast cancer.

Colon – CD141 negative colorectal adenocarcinoma (CD141 immunohistochemistry).

Esophagus – Squamous cell carcinoma with strong CD141 immunostaining of a fraction of tumor cells (CD141 immunohistochemistry).

Kidney – CD141 negative clear cell carcinoma. Only small vessels show endothelial staining (CD141 immunohistochemistry).

Kidney – Papillary renal cell carcinoma showing moderate to strong membranous and cytoplasmic CD141 staining of tumor cells (CD141 immunohistochemistry).

Lung – CD141 negative adenocarcinoma. Positive staining is limited to alveolar macrophages and small vessels show endothelial staining (CD141 immunohistochemistry).

Lung – CD141 negative small cell carcinoma.

Lung – Malignant mesothelioma with strong CD141 immunostaining of tumor cells (CD141 immunohistochemistry).

Lymph node – Hogkin and Reed-Sternberg cells are CD141 negative in a Hodgkin’s lymphoma.

Oral cavity – CD141 negative squamous cell carcinoma. Staining is only seen in endothelial cells (CD141 immunohistochemistry).

Ovary – CD141 negative serous high-grade carcinoma. Significant endothelial staining occurs in small vessels (CD141 immunohistochemistry).

Pancreas – CD141 negative acinar cell carcinoma containing small vessels showing endothelial CD141 staining (CD141 immunohistochemistry).

Pancreas – Neuroendocrine tumor showing weak to moderate CD141 staining of tumor cells.

Prostate – Adenocarcinoma (Gleason 4+5=9) with moderate to strongmembranous and cytoplasmic CD141 staining of tumor cells (CD141 immunohistochemistry).

Prostate – CD141 negative adenocarcinoma (Gleason 3+3=6).

Salivary gland – CD141 immunostaining is absent in epithelial cells of a Warthin tumor (CD141 immunohistochemistry).

Skin – Basal cell carcinoma with strong CD141 immunostaining of a “maturing” fraction of tumor cells (CD141 immunohistochemistry).

Skin – CD141 negative Merkel cell carcinoma.

Soft tissue – Granular cell tumor exhibiting strong cytoplasmic CD141 immunostaining of tumor cells (CD141 immunohistochemistry).

Soft tissue – Liposarcoma with strong CD141 immunostaining of tumor cells (CD141 immunohistochemistry).

Stomach – Gastrointestinal stromal tumor (GIST) with moderate to strong CD141 immunostaining of tumor cells (CD141 immunohistochemistry).

Testis – CD141 negative seminoma. Staining is only seen in endothelial cells (CD141 immunohistochemistry).

Testis – Leydig cell tumor exhibiting a strong CD141 immunostaining of tumor cells (CD141 immunohistochemistry).

Thyroid – Anaplastic carcinoma with strong CD141 immunostaining of tumor cells (CD141 immunohistochemistry)

Thyroid – CD141 negative papillary carcinoma. Staining is limited to few endothelial cells (CD141 immunohistochemistry).

Thyroid – Follicular adenoma with weak – predominantly cytoplasmic – CD141 immunostaining of tumor cells. Endothelial cells show strong staining (CD141 immunohistochemistry).

Urinary bladder – CD141 negative muscle-invasive urothelial carcinoma.

Urinary bladder – Muscle-invasive urothelial carcinoma with strong membranous CD141 immunostaining of tumor cells (CD141 immunohistochemistry).

Urinary bladder – Non-invasive urothelial carcinoma (high grade, pTaG3) with strong CD141 immunostaining of tumor cells (CD141 immunohistochemistry).

Uterus – CD141 negative leiomyosarcoma. Staining is limited to endothelial cells (CD141 immunohistochemistry).

Uterus, cervix – CD141 negative adenocarcinoma. Only small vessels show endothelial staining (CD141 immunohistochemistry).

Uterus, cervix – CD141 negative squamous cell carcinoma.

Uterus, cervix – Squamous cell carcinoma with strong CD141 immunostaining of tumor cells (CD141 immunohistochemistry).