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Adrenal gland – CASP3 negative adrenocortical adenoma
Adrenal gland – CASP3 negative pheochromocytoma
Breast – CASP3 negative invasive lobular breast cancer
Breast – Invasive breast cancer of no special type (NST) showing a moderate to strong CASP3 reactivity of tumor cells
Colon – CASP3 negative colorectal adenocarcinoma
Colon – Colorectal adenocarcinoma with strong CASP3 staining of all tumor cells
Esophagus – Adenocarcinoma showing a moderate to strong CASP3 staining of tumor cells
Kidney – CASP3 negative clear cell carcinoma
Kidney – CASP3 negative papillary renal cell carcinoma
Larynx – Squamous cell carcinoma with strong CASP3 staining of tumor cells
Liver – CASP3 negative cholangiocellular carcinoma
Liver – CASP3 negative hepatocellular carcinoma. Strong CASP3 positivity of some interspersed lymphocytes
Lung – Adenocarcinoma with strong CASP3 positivity of tumor cells. Strong CASP3 is also seen in intermingled non-neoplastic lymphocytes
Lung – CASP3 negative squamous cell carcinoma
Lung – Epitheloid mesothelioma with faint CASP3 positivity of tumor cells
Lymph node – CASP3 negative B-CLL. Strong CASP3 positivity of few intermingled non-neoplastic lymphocytes
Lymph node – CASP3 negative Hodgkin’s lymphoma. Strong CASP3 positivity of some non-neoplastic lymphocytes
Lymph node – Diffuse large B-cell lymphoma exhibiting a strong CASP3 immunostaining of all tumor cells
Lymph node – Diffuse large B-cell lymphoma with strong CASP3 staining of tumor cells
Lymph node – Hodgkin’s lymphoma with intense CASP3 staining of Hodgkin’s and Reed-Sternberg cells
Lymph node – Hodgkin’s lymphoma with only a faint CASP3 staining of tumor cells. Strong CASP3 positivity of a large fraction of non-neoplastic lymphocytes
Ovary – CASP3 negative serous high-grade carcinoma showing CASP3 positivity of intermingled lymphocytes
Ovary – Serous high-grade carcinoma with strong CASP3 staining of scattered cells
Pancreas – Adenocarcinoma of the papilla Vaterii with strong CASP3 staining of tumor cells
Pancreas – CASP3 negative neuroendocrine tumor
Pancreas – Ductal adenocarcinoma with moderate to strong CASP3 positivity of tumor cells
Penis – Squamous cell carcinoma with moderate CASP3 staining of tumor cells. CASP3 staining is stronger in intermingled lymphocytes
Penis – Squamous cell carcinoma with moderate to strong CASP3 staining of tumor cells
Pharynx – Squamous cell carcinoma showing strong CASP3 staining of all tumor cells
Prostate – CASP3 negative adenocarcinoma (Gleason 3+3=6)
Salivary gland – CASP3 negative Warthin tumor. Some of the intermingled lymphocytes are CASP3 positive
Soft tissue – CASP3 negative leiomyosarcoma
Soft tissue – Chondrosarcoma with a weak CASP3 staining of tumor cells. Strong CASP3 positivity of intermingled lymphocytes
Soft tissue – Leiomyosarcoma with a variable, weak to strong CASP3 staining of tumor cells
Stomach – CASP3 negative gastrointestinal stromal tumor (GIST)
Stomach – Gastric adenocarcinoma (diffuse type) with strong CASP3 positivity of tumor cells
Stomach – Gastric adenocarcinoma (intestinal type) with strong CASP3 staining of all tumor cells
Testis – CASP3 negative Leydig cell tumor
Testis – CASP3 negative seminoma. Strong CASP3 positivity of intermingled lymphocytes
Testis – Embryonal carcinoma with strong CASP3 immunostaining of all tumor cells
Testis – Seminoma with weak CASP3 staining of tumor cells
Thyroid – Anaplastic carcinoma with strong CASP3 staining of all tumor cells
Thyroid – CASP3 negative papillary carcinoma
Urinary bladder – Muscle-invasive urothelial carcinoma with intense CASP3 positivity of tumor cells
Uterus, cervix – Adenocarcinoma with strong CASP3 staining of tumor cells
Uterus, cervix – CASP3 negative squamous cell carcinoma