Adrenal gland – Faint membranous CLDN3 staining of few epithelial cells
Adrenal gland – No CLDN3 staining in this sample
Aorta, media
Appendix, muscular wall
Bone marrow – Distinct membranous CLDN3 staining of megacaryocytes
Breast – Strong membranous CLDN3 staining of luminal cells
Bronchus, mucosa – Strong membranous CLDN3 staining of respiratory epithelial cells
Cerebellum (white matter)
Cerebellum, cortex (molecular layer, Purkinje cell layer, granule cell layer)
Cerebrum, grey matter
Cerebrum, white matter
Colon descendens, mucosa – Strong membranous CLDN3 staining of all epithelial cells
Colon descendens, muscular wall
Duodenum, Brunner gland
Duodenum, mucosa – Strong membranous CLDN3 staining of all epithelial cells
Epididymis (Cauda) – Strong membranous CLDN3 staining of most epithelial cells
Epididymis (Corpus) – Faint membranous CLDN3 staining of chief cells
Esophagus, squamous epithelium
Fallopian tube, mucosa – Strong membranous CLDN3 staining of epithelial cells
Fat
Gallbladder, epithelium – Moderate to strong membranous CLDN3 staining of epithelial cells
Ileum, mucosa – Strong membranous CLDN3 staining of all epithelial cells
Kidney, cortex – A strong membranous CLDN3 staining preferentially occurs in collecting ducts but can also be seen in individual tubular cells
Kidney, medulla – A membranous CLDN3 staining of variable intensity occurs in collecting ducts
Kidney, pelvis, urothelium – Weak to strong membranous CLDN3 staining of a subset of urothelial cells, predominantly in the upper half of the urothelium
Liver – Moderate membranous CLDN3 staining of hepatocytes
Liver – Strong membranous CLDN3 staining of bile ducts. Weak to moderate membranous CLDN3 staining of hepatocytes, predominantly at the bile secreting pole
Lung – Faint membranous CLDN3 staining of some pneumocytes
Lung – Strong membranous CLDN3 staining of bronchiolized alveolar cell. CLDN3 staining is only faint in regular pneumocytes
Lymph node – Strong luminal membranous CLDN3 staining of at least a subset of high endothelial venules. Moderate to strong CLDN3 staining of a subset of cells in germinal centres
Lymph node – Strong luminal membranous CLDN3 staining of at least a subset of high endothelial venules
Ovary, corpus luteum – Weak to moderate, membranous CLDN3 staining of at least a large subset of corpus luteum cells
Ovary, stroma
Pancreas – Strong membranous CLDN3 staining of acinar cells. Staining is weaker in cells of islets of Langerhans
Pancreas – Strong membranous CLDN3 staining of acinar cells
Parathyroid gland – Weak to moderate membranous CLDN3 staining of epithelial cells
Parotid gland – Strong membranous CLDN3 staining of glandular cells. CLDN3 staining is only very faint in excretory duct cells
Pituitary gland, anterior lobe – Moderate membranous CLDN3 staining of a subset of epithelial cells
Pituitary gland, posterior lobe
Placenta (amnion and chorion)
Placenta, early – Faint to moderate, membranous CLDN3 staining of the surface membrane of the syncytiotrophoblast
Placenta, mature – No CLDN3 staining in this sample
Placenta, mature – Various endothelial cells show a distinct CLDN3 staining
Prostate – Strong membranous CLDN3 staining of basal and acinar epithelial cells
Rectum, mucosa – Strong membranous CLDN3 staining of all epithelial cells
Seminal vesicle – Moderate to strong membranous CLDN3 staining of epithelial cells
Sinus paranasales – Strong membranous CLDN3 staining of respiratory epithelial cells
Skeletal muscle
Skin, hairfollicel and sebaceous glands
Skin
Spleen – Moderate to strong CLDN3 staining of a subset of cells in the white pulp
Stomach, antrum – Distinct membranous CLDN3 positivity of few epithelial cells in the neck and in glandular pits
Stomach, antrum – Strong membranous CLDN3 staining of a small subset of epithelial cells in the neck and in glandular pits
Submandibular gland – Strong membranous CLDN3 staining of glandular cells. CLDN3 staining is only very faint in excretory duct cells
Testis
Thymus – Strong membranous CLDN3 staining of cells of corpuscles of Hassall’s
Thyroid gland – Moderate to strong membranous CLDN3 staining of follicular epithelial cells
Tonsil – Strong membranous CLDN3 staining of squamous epithelial cells of the crypts
Tonsil, surface epithelium
Urinary bladder, muscular wall
Urinary bladder, urothelium – Weak to strong membranous CLDN3 staining of a subset of urothelial cells, predominantly in the upper half of the urothelium
Uterus, ectocervix
Uterus, endocervix – Strong, predominantly basolateral membranous CLDN3 staining of epithelial cells
Uterus, endometrium (pregnancy) – Strong membranous CLDN3 staining of epithelial cells
Uterus, endometrium (proliferation) – Strong membranous CLDN3 staining of epithelial cells
Uterus, endometrium (secretion) – Strong membranous CLDN3 staining of epithelial cells
Uterus, myometrium